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Association of baseline factors with 1-year outcomes in the SB11-ranibizumab equivalence trial: A post hoc analysis.

Se Joon WooJin Ah JungTaehyung KimInkyung OhMercy Yeeun KimNeil M Bressler
Published in: Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) (2024)
Post hoc analyses of the SB11-rRBZ equivalence study showed that baseline age, BCVA, CST, and total lesion area were prognostic factors for visual or anatomical outcomes of nAMD, while subgroup analyses demonstrated comparable results for SB11 and rRBZ. Collectively, the results appear comparable to similar RCTs of anti-vascular endothelial growth factor reference products for nAMD and strengthen confidence in the biosimilarity of SB11.
Keyphrases
  • vascular endothelial growth factor
  • prognostic factors
  • phase iii
  • clinical trial
  • endothelial cells
  • type diabetes
  • adipose tissue
  • glycemic control
  • skeletal muscle
  • age related macular degeneration
  • insulin resistance