MYO5B and the Polygenic Landscape of Very Early-Onset Inflammatory Bowel Disease in an Ethnically Diverse Population.

Ashleigh WatsonR Alan HarrisAmy C EngevikNuman OezguenMaribeth R NicholsonSarah DooleyRachel StublerLisa Forbes SatterLina B KaramRichard Kellermayer

Published in: Inflammatory bowel diseases (2024)

Our results support the polygenic nature of VEO-IBD, in which key participants, like MYO5B, were identified through network analytics. Rare variant load within susceptibility genes may be relevant not only for the genetic origins of inflammatory bowel disease, but also for the age of disease onset. Our findings could guide future work in precision medicine.

Keyphrases

early onset
late onset
genome wide
ulcerative colitis
big data
current status
single cell
dna methylation
copy number