Complicated Long Term Vaccine Induced Thrombotic Immune Thrombocytopenia-A Case Report.

Albrecht GüntherDirk BrämerMathias W PletzThomas KamradtSabine BaumgartThomas E MayerMichael BaierAngelina AutschChristian MawrinLinda SchönbornAndreas GreinacherThomas Thiele

Published in: Vaccines (2021)

Complicated VITT with extremely high anti-PF4-IgG titers over three months can induce recurrent thrombocytopenia despite treatment with IVIG and anticoagulation. Plasma exchange, immunoadsorption, and /or immunosuppressive treatment may be considered in complicated VITT to reduce extraordinarily high levels of anti-PF4-IgG. Long-term therapy in such cases must take the individual bleeding risk and CSVT risk into account.

Keyphrases

atrial fibrillation
stem cells
venous thromboembolism
combination therapy
mesenchymal stem cells
bone marrow
drug induced
replacement therapy