Intracellular Toxic Advanced Glycation End-Products in 1.4E7 Cell Line Induce Death with Reduction of Microtubule-Associated Protein 1 Light Chain 3 and p62.

Takanobu Takata Akiko Sakai-Sakasai Masayoshi Takeuchi

Published in: Nutrients (2022)

Intracellular TAGE induced death of β-cells more strongly than extracellular TAGE, and may suppress autophagy via reduction of LC3-I, LC3-II, and p62 to inhibit the degradation of them.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
simultaneous determination
cell cycle arrest
cell death
reactive oxygen species
oxidative stress
signaling pathway
diabetic rats
high glucose
mass spectrometry
liquid chromatography
cell proliferation
pi k akt
high resolution mass spectrometry