Evaluation of local tissue peri-implant reaction in total knee arthroplasty failure cases.

Ava BrozovichTerry ClyburnKevin ParkKatharine D HarperThomas SullivanStephen IncavoFrancesca Taraballi

Published in: Therapeutic advances in musculoskeletal disease (2022)

These data support metal hypersensitivity, mediated by a T4HR, for some cases of TKA failure. Current methods to screen patients for metal hypersensitivity prior to primary TKA have been inclusive. This study demonstrates the need for a more sensitive screening test from specimens in the knee joint, to more accurately identify patients who will exhibit a T4HR to metal.

Keyphrases

total knee arthroplasty
end stage renal disease
total hip
chronic kidney disease
newly diagnosed
ejection fraction
drug induced
peritoneal dialysis
prognostic factors
electronic health record
machine learning
patient reported outcomes
data analysis
fine needle aspiration