Mesiotemporal Volumetry, Cortical Thickness, and Neuropsychological Deficits in the Long-term Course of Limbic Encephalitis.
Antonia HarmsTobias BauerJuri-Alexander WittTobias BaumgartnerRandi von WredeAttila RaczLeon ErnstAlbert J BeckerChristoph HelmstaedterRainer SurgesTheodor RuberPublished in: Neurology(R) neuroimmunology & neuroinflammation (2023)
Our data depict higher mesiotemporal volumes in the early disease stage, most likely due to edematous swelling, followed by volume regression and atrophy/hippocampal sclerosis in the late disease stage. Our study reveals a continuous and pathophysiologically meaningful trajectory of mesiotemporal volumetry across all serogroups and provides evidence that LE should be considered a network disorder in which extratemporal involvement is an important determinant of disease severity.