Association study identified HLA-DQA1 as a novel genetic risk of systemic lupus erythematosus-associated pulmonary arterial hypertension.

This study, based on the largest cohort of SLE-associated PAH, is the first to investigate MHC region genetic variants contribute to SLE-associated PAH susceptibility. HLA-DQA1*03:02 is a novel genetic risk factor and a prognostic factor in SLE-associated PAH. SLE patients with this allele require regular monitoring and careful follow-up for early diagnosis and interventions for potential PAH. This article is protected by copyright. All rights reserved.