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Synthesis and Characterization of Heterobenzenacyclo-octaphanes Derived from Cyclotetrabenzoin.

Sebastian HahnMaymounah AlrayyaniAnna SontheimXiqu WangFrank RomingerOgnjen Š MiljanićUwe H F Bunz
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2017)
We describe the modular synthesis and characterization of several substituted N-hetero benzenacyclooctaphanes (BAOs), a new motif for heteroaromatic conjugated macrocycles. The targets were synthesized via condensation of substituted aromatic ortho-diamines with a cyclic octaketone building block in moderate to excellent yields (41-91 %). We evaluated the optical and electronic properties and the solid-state structures of the targets and discuss their properties through comparison with their linear diphenyl N-heteroacene counterparts.
Keyphrases
  • solid state
  • molecular docking
  • high resolution
  • photodynamic therapy
  • high intensity
  • molecular dynamics simulations