Somatic hits in mismatch repair genes in colorectal cancer among non-seminoma testicular cancer survivors.

Berbel L M YkemaEmilie C H BreekveldtBeatriz Carvalho J Tom van WezelGerrit A MeijerMartijn KerstMichael SchaapveldFlora E van LeeuwenPetur Snaebjornsson Monique E van Leerdam

Published in: British journal of cancer (2022)

MMRd CRCs with somatic double or single hit are more frequent in this small cohort of TCS compared with P-CRC. Exposure to anticancer treatments appears to be associated with the development of these rare MMRd CRC among cancer survivors.

Keyphrases

young adults
germ cell
copy number
childhood cancer
genome wide
bioinformatics analysis
genome wide identification
dna methylation
gene expression