129 Xe Hyper-CEST/ 19 F MRI Multimodal Imaging System for Sensitive and Selective Tumor Cells Detection.

Heteronuclear MRI offers broad potential for specific detection and quantification of molecularly targeted agents in diagnosis and therapy planning or monitoring. Here we report a novel method for simultaneous acquisition of dual-nuclei hyper-CEST 129 Xe and 19 F tumor targeting MRI. 129 Xe hyper-CEST MRI, 19 F MRI and fluorescent imaging were integrated into PFOB nanoemulsion as a imaging system for sensitive and selective tumor cells detection. As the complement to 1 H MRI, 129 Xe and 19 F signals can also provide efficient and precise anatomical localization of tumors.