Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells.
Kevin W SoutherlandYueyuan XuDerek T PetersXin LinXiaolin WeiYu XiangKaileen FeiLindsey A OlivereJeremy M MorowitzJames OttoQunsheng DaiChristopher D KontosYarui DiaoPublished in: Genome medicine (2023)
Collectively, our research provides the first single-cell transcriptome atlases of skeletal muscle from CLTI patients and a murine CLTI model, emphasizing the crucial role of macrophages and inflammation in regulating muscle regeneration in CLTI through interactions with MuSCs.
Keyphrases
- skeletal muscle
- single cell
- stem cells
- end stage renal disease
- insulin resistance
- rna seq
- induced apoptosis
- newly diagnosed
- oxidative stress
- chronic kidney disease
- peritoneal dialysis
- gene expression
- cell cycle arrest
- high throughput
- adipose tissue
- cell proliferation
- metabolic syndrome
- type diabetes
- blood brain barrier
- brain injury
- endoplasmic reticulum stress
- cerebral ischemia