New Alkaloids and Steroids from Hydranth of Goniopora columna Corals and Their Inhibiting Lung Cancer Cell Activities.
Guangfu FengJieyi HeQiqi LiMeng BaiKai LiuXinming LiuXiangxi YiYonghong LiuLianxiang LuoCheng-Hai GaoPublished in: Chemistry & biodiversity (2024)
A new alkaloids, aplysingoniopora A (1), and new configuration pregnane type steroid compound, 9,17-α-pregn-1,4,20-en-3-one (2), and two known pregnane type steroid compounds (3 and 4) were isolated from hydranth of Goniopora columna corals. The compounds structures and absolute configurations were determined by extensive spectroscopic analysis, MS data, single-crystal X-ray diffraction analysis and quantum chemical calculation. The anticancer effect of the compounds were explored in human non-small-cell lung cancer (NSCLC) A549 cell lines. As the results, the compound 3 and 4 induces toxicity and has proliferation inhibitory effects on A549 cells (IC 50 =58.99 μM and 58.77 μM, respectively) in vitro.
Keyphrases
- signaling pathway
- small cell lung cancer
- induced apoptosis
- high resolution
- endothelial cells
- mass spectrometry
- oxidative stress
- ms ms
- magnetic resonance imaging
- molecular docking
- cell cycle arrest
- machine learning
- big data
- advanced non small cell lung cancer
- artificial intelligence
- deep learning
- pi k akt
- brain metastases
- energy transfer