Electrochemically stimulated drug release from flexible electrodes coated electrophoretically with doxorubicin loaded reduced graphene oxide.

Lijie HeSujoy SarkarAlexandre BarrasRabah Boukherroub Sabine Szunerits Daniel Mandler

Published in: Chemical communications (Cambridge, England) (2018)

The electrochemically triggered release of doxorubicin (DOX) from flexible electrodes modified electrophoretically with reduced graphene oxide (rGO)-DOX is reported. The release is driven by a positive potential pulse that decreases the pH of the rGO-DOX surface locally, which is confirmed by scanning electrochemical microscopy (SECM) in situ. In vitro cell viability tests confirms that the delivery system meets therapeutic needs.

Keyphrases

reduced graphene oxide
gold nanoparticles
drug delivery
cancer therapy
high resolution
label free
blood pressure
single molecule
high throughput
solid state
optical coherence tomography
electron microscopy
emergency department
human health
risk assessment
mass spectrometry
climate change
drug induced