Chemical Composition of Artemisia Scoparia and Their Bioactivities.
Guziliayi KuerbanAblajan TurakNurmirza Boymirzayevich BegmatovJiangyu ZhaoHaji Akber AisaPublished in: Chemistry & biodiversity (2024)
Three undescribed sesquiterpenes (1-3), two enantiomeric pairs of monoterpenes (4a/4b-5a/5b), one alkyne (6), two known alkynes (7-8) and eight known coumarins (9-16) were isolated from the aerial parts extracts of Artemisia scoparia. The structures of these compounds were fully elucidated by their 1D and 2D NMR, HRESIMS spectral data analyses, and comparison with literature. The absolute configurations of compounds were determined by single-crystal X-ray crystallography (1), a comparison of experimental and calculated electronic circular dichroism (ECD) data (2-6). 15 showed moderate inhibitory activity with the NO release in LPS-induced RAW264.7 cells. 9-16 showed varying degrees of promoting melanogenesis and tyrosinase activity in B16 cells.
Keyphrases
- lps induced
- high resolution
- inflammatory response
- electronic health record
- induced apoptosis
- big data
- systematic review
- magnetic resonance
- cell cycle arrest
- dual energy
- solid state
- high intensity
- signaling pathway
- machine learning
- oxidative stress
- magnetic resonance imaging
- cell proliferation
- artificial intelligence
- mass spectrometry