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BRCA1 and BRCA2 gene variants and nonsyndromic cleft lip/palate.

Nicholas RodriguezLorena MailiBrett T ChiquetSusan H BlantonJacqueline T HechtAriadne Letra
Published in: Birth defects research (2018)
Our results suggest a modest association between BRCA1 and BRCA2 and NSCL/P. Further studies in additional populations and functional studies are needed to elucidate the role of these genes in developmental processes and signaling pathways contributing to NSCL/P.
Keyphrases
  • breast cancer risk
  • copy number
  • genome wide
  • signaling pathway
  • case control
  • gene expression
  • epithelial mesenchymal transition
  • dna methylation
  • pi k akt
  • cell proliferation
  • bioinformatics analysis