Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome.
Priyanka GorijalaM Muaaz AslamLam-Ha T DangL XicotaMaria V FernandezYun Ju SungKang-Hsien FanEleanor FeingoldEzequiel I SuraceJasmeer P ChhatwalChristy L Homnull nullnull nullSigan L HartleyJason HassenstabRichard J PerrinMark MapstoneShahid H ZamanBeau M AncesM Ilyas KambohJoseph H LeeCruchaga CarlosPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Examination of the polygenic risk of AD in DS presented here is the first of its kind. AD PRS influences memory aspects in DS individuals, independently of APOE genotype. These results point to an overlap between the genes and pathways that leads to AD and those that influence dementia and memory decline in the DS population. APOE ε4 is linked to DS cognitive decline, expanding cognitive insights in adults.