A novel aureothin diepoxide derivative from Streptomyces sp. NIIST-D31 strain.

Thankappan DrissyaD K IndujaM S PoornimaA R S JesminaBernard PrabhaMathew SauminiCherumuttathu H SureshK G RaghuB S Dileep KumarRavi S Lankalapalli

Published in: The Journal of antibiotics (2022)

A novel vicinal diepoxide of alloaureothin was isolated from Streptomyces sp. NIIST-D31 strain along with three carboxamides, p-aminobenzoic acid and 1,6-dimethoxyphenazine. Exhaustive 2D NMR analysis and analysis of experimental, theoretical CD spectra aided in establishing the structure of compound 1. Compound 1 inhibits adipogenesis and accumulation of lipid droplets during the differentiation of 3T3-L1 cells.

Keyphrases

induced apoptosis
cell cycle arrest
magnetic resonance
cell death
endoplasmic reticulum stress
oxidative stress
density functional theory
mass spectrometry
skeletal muscle
pi k akt
insulin resistance
molecular dynamics
data analysis