Intrapulmonary Autoantibodies to HSP72 Are Associated with Improved Outcomes in IPF.

Ross MillsAbhinav MathurLisa M NicolJeremy J WalkerAlexander A PrzybylskiAlison C MackinnonSarah E M HowieWilliam A H WallaceIan DransfieldNikhil Hirani

Published in: Journal of immunology research (2019)

Our results indicate that intrapulmonary anti-Hsp72 antibodies are associated with improved outcomes in IPF. These may represent natural autoantibodies, and anti-Hsp72 IgM and IgA may provide a beneficial role in disease pathogenesis, though the mechanism of action for this has yet to be determined.

Keyphrases

heat shock protein
heat shock
heat stress
idiopathic pulmonary fibrosis
systemic lupus erythematosus
type diabetes
adipose tissue
metabolic syndrome
oxidative stress
insulin resistance