Maresin 1 Alleviates Diabetic Kidney Disease via LGR6-Mediated cAMP-SOD2-ROS Pathway.

Xinyue Li Butuo Xu Jing Wu Yueli Pu Sheng-Rong Wan Yan Zeng Mei Wang Lifang Luo Fanjie Zhang Zong-Zhe Jiang Yong Xu

Published in: Oxidative medicine and cellular longevity (2022)

Our study demonstrates that decreased serum MaR1 levels were correlated with the development of DKD. MaR1 could alleviate DKD and glucotoxicity-induced inflammation via LGR6-mediated cAMP-SOD2 antioxidant pathway. Thus, our present findings identify MaR1 as a predictor and a potential therapeutic target for DKD.

Keyphrases

oxidative stress
diabetic rats
amyotrophic lateral sclerosis
binding protein
type diabetes
dna damage
high glucose
cell death
protein kinase
reactive oxygen species
anti inflammatory
human health
risk assessment
endothelial cells