Maresin 1 Alleviates Diabetic Kidney Disease via LGR6-Mediated cAMP-SOD2-ROS Pathway.
Xinyue LiButuo XuJing WuYueli PuSheng-Rong WanYan ZengMei WangLifang LuoFanjie ZhangZong-Zhe JiangYong XuPublished in: Oxidative medicine and cellular longevity (2022)
Our study demonstrates that decreased serum MaR1 levels were correlated with the development of DKD. MaR1 could alleviate DKD and glucotoxicity-induced inflammation via LGR6-mediated cAMP-SOD2 antioxidant pathway. Thus, our present findings identify MaR1 as a predictor and a potential therapeutic target for DKD.