Scaling factors for the in vitro-in vivo extrapolation (IV-IVE) of renal drug and xenobiotic glucuronidation clearance.

Kathleen M KnightsShane M SpencerJohn K FallonNuy ChauPhilip C SmithJohn O Miners

Published in: British journal of clinical pharmacology (2016)

Scaled renal PRO glucuronidation CLint,u,UGT was double that of liver. Renal CLint,u,UGT should be accounted for in the IV-IVE of UGT1A9 and considered for UGT1A6 and 2B7 substrates.

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