Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study.

Päivi Herranen Kaisa Koivunen Teemu PalviainenUrho M KujalaSamuli RipattiJaakko KaprioElina Sillanpää

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2024)

The genotype that supports higher muscle strength appears to protect against future health adversities, albeit with modest effect sizes. Further research is needed to investigate whether or how a favourable lifestyle modifies this intrinsic capacity to resist diseases, and if the impacts of lifestyle behaviour on health differ due to genetic predisposition for muscle strength.

Keyphrases

genome wide
public health
healthcare
metabolic syndrome
mental health
cardiovascular disease
physical activity
dna methylation
health information
weight loss
type diabetes
gene expression
human health