Proteomics and mathematical modeling of longitudinal CSF differentiates fast versus slow ALS progression.

Lucas VuKrystine Garcia-MansfieldAntonio PompeianoJiyan AnVictoria David-DirgoRitin SharmaVinisha VenugopalHarkeerat HalaitGuido MarcucciYa-Huei KuoLisa UechiRussell C RocknePatrick PirrotteRobert Bowser

Published in: Annals of clinical and translational neurology (2023)

We identified pathways and protein biomarkers that distinguish rate of ALS disease progression. A mathematical model of the CSF proteome determined that the change in entropy of the proteome over time was predictive of FP versus SP.

Keyphrases

amyotrophic lateral sclerosis
mass spectrometry
protein protein
binding protein
small molecule