Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes.

Jay N JoshiNeha ChangelaLia MahalTyler DefosseJanet JangLin-Ing WangArunika DasJoanatta G ShapiroKim S McKim

Published in: bioRxiv : the preprint server for biology (2024)

Kinetochore proteins regulate meiosis specific functions. SPC105R is a central regulator of kinetochore function but its role in meiosis is not well understood.We identified regions of SPC105R that regulate key meiosis I functions, including fusing sister centromeres and the way the kinetochore interacts with the microtubules.SPC105R is a hub that recruits several proteins to regulate kinetochore activity. Future work will involve identifying the proteins recruited by SPC105R that mediate these functions in meiosis.

Keyphrases

transcription factor
binding protein
gene expression
copy number
small molecule
network analysis
amino acid