Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial.

Carlo Scognamiglio Renner AraujoAna Cristina Medeiros-RibeiroCarla G S SaadKarina Rossi BonfiglioliDiogo Souza DomicianoAndrea Yukie ShimabucoMatheus Santos Rodrigues SilvaEmily Figueiredo Neves YukiSandra Gofinet PasotoTatiana PedrosaLeonard de Vinci Kanda KupaGioanna ZouRosa M R PereiraClóvis Artur SilvaNádia Emi Aikawa Eloisa S Bonfa

Published in: Annals of the rheumatic diseases (2022)

We provided novel data that 2-week MTX withdrawal after each dose of the Sinovac-CoronaVac vaccine improves anti-SARS-CoV-2 IgG response. The increased flare rates after the second MTX withdrawal may be attributed to the short-term interval between vaccine doses. This strategy requires close surveillance and shared decision making due to the possibility of flares.

Keyphrases

sars cov
clinical trial
respiratory syndrome coronavirus
placebo controlled
open label
double blind
big data
phase iii
artificial intelligence
coronavirus disease