Gliadin-reactive T cells in Italian children from preventCD cohort at high risk of celiac disease.
Alessandra CamarcaRenata AuricchioStefania PicasciaOlga FierroMariantonia MaglioErasmo MieleBasilio MalamisuraLuigi GrecoRiccardo TronconeCarmen GianfraniPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2018)
T cells reactive to gliadin can be detected in the intestine of children at high risk of developing CD, in some cases also in the presence of a normal mucosa and negative CD-associated antibodies. Furthermore, children at a very early stage of CD recognize the same gliadin epitopes that are active in adult CD patients. Tissue transglutaminase strongly enhances gluten T-cell immunogenicity in early CD.