Login / Signup

Epigenetic escape of immunosurveillance by malignant cell precursors.

Claudia GalassiLorenzo Galluzzi
Published in: The EMBO journal (2023)
Newly formed malignant cells must escape immunosurveillance to generate progressing neoplastic lesions of clinical relevance. Recent data indicate that the immunogenicity of nascent cancer cells, at least in some settings, is dictated by inherent epigenetic mechanisms rather than by immunoediting and the consequent Darwinian selection of poorly immunogenic phenotypes.
Keyphrases
  • dna methylation
  • induced apoptosis
  • gene expression
  • single cell
  • cell cycle arrest
  • electronic health record
  • signaling pathway
  • bone marrow
  • mesenchymal stem cells
  • deep learning
  • artificial intelligence