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Prognostic role of red blood cell distribution width and platelet/lymphocyte ratio in early-stage classical Hodgkin lymphoma.

Yunxia TaoYu ZhouHaizhu ChenYan QinXiaohui HePeng LiuShengyu ZhouJianliang YangLiqiang ZhouChanggong ZhangSheng YangLin GuiYuan-Kai Shi
Published in: Future oncology (London, England) (2022)
Background: To investigate the prognostic role of red blood cell distribution width (RDW) and platelet/lymphocyte ratio (PLR) in early-stage classical Hodgkin lymphoma (cHL). Materials & methods: Data from 402 patients with newly diagnosed early-stage cHL were retrospectively collected. The impact of factors on complete response (CR) rate and freedom from progression (FFP) was analyzed. Results: High PLR was associated with lower CR, but high RDW was not. The univariate analysis showed that RDW and PLR were predictive of FFP. On multivariate analysis, high PLR was an independent risk factor for inferior FFP. Subgroup analysis and a prognostic model for FFP based on PLR validated the prognostic role of PLR. Conclusion: PLR was a robust prognostic factor for newly diagnosed early-stage cHL.
Keyphrases
  • early stage
  • hodgkin lymphoma
  • red blood cell
  • newly diagnosed
  • sentinel lymph node
  • radiation therapy
  • machine learning
  • data analysis
  • big data
  • electronic health record
  • open label
  • study protocol
  • rectal cancer