Water-Compatible and Recyclable Heterogeneous SABRE Catalyst for NMR Signal Amplification.
Sein MinJuhee BaekJisu KimHye Jin JeongJean K ChungKeunhong JeongPublished in: JACS Au (2023)
A water-compatible and recyclable catalyst for nuclear magnetic resonance (NMR) hyperpolarization via signal amplification by reversible exchange (SABRE) was developed. The [Ir(COD)(IMes)Cl] catalyst was attached to a polymeric resin of bis(2-pyridyl)amine (heterogeneous SABRE catalyst, HET-SABRE catalyst), and it amplified the 1 H NMR signal of pyridine up to (-) 4455-fold (43.2%) at 1.4 T in methanol and (-) 50-fold (0.5%) in water. These are the highest amplification factors ever reported among HET-SABRE catalysts and for the first time in aqueous media. Moreover, the HET-SABRE catalyst demonstrated recyclability by retaining its activity in water after more than three uses. This newly designed polymeric resin-based heterogeneous catalyst shows great promise for NMR signal amplification for biomedical NMR and MRI applications in the future.
Keyphrases
- ionic liquid
- magnetic resonance
- highly efficient
- room temperature
- carbon dioxide
- reduced graphene oxide
- metal organic framework
- high resolution
- solid state
- visible light
- nucleic acid
- contrast enhanced
- drug delivery
- gold nanoparticles
- magnetic resonance imaging
- big data
- diffusion weighted imaging
- mass spectrometry
- cancer therapy