Metabolic Profiling of Obesity With and Without the Metabolic Syndrome: A Multisample Evaluation.
Lars LindSamira SalihovicJohan SundströmSölve ElmståhlUlf HammarKoen DekkersJohan ÄrnlövJ Gustav SmithGunnar EngströmTove FallPublished in: The Journal of clinical endocrinology and metabolism (2022)
Our data suggest a graded derangement of the circulating metabolite profile from lean to obese to MetS, in particular for metabolites involved in amino acid synthesis/metabolism and sphingolipid metabolism. Insulin resistance is a plausible mediator of this gradual metabolic deterioration.
Keyphrases
- metabolic syndrome
- insulin resistance
- adipose tissue
- amino acid
- high fat diet
- high fat diet induced
- uric acid
- type diabetes
- weight loss
- polycystic ovary syndrome
- skeletal muscle
- cardiovascular risk factors
- single cell
- big data
- electronic health record
- body mass index
- physical activity
- bariatric surgery
- postmenopausal women
- deep learning