Iridium-Catalyzed β-Alkynylation of Aliphatic Oximes as Masked Carbonyl Compounds and Alcohols.

An Ir-catalyzed C(sp3 )-H alkynylation of aliphatic ketones, aldehydes, and alcohols was achieved by using the corresponding oxime derivatives and a IrIII catalyst. This general reaction is selective towards primary C(sp3 )-H bonds and can be used for the late-stage C-H alkynylation of complex molecules.