Eicosapentaenoic acid potentiates the therapeutic effects of adipose tissue-derived mesenchymal stromal cells on lung and distal organ injury in experimental sepsis.
Johnatas D SilvaMiquéias Lopes-PachecoLigia L de CastroJamil Z KitokoStefano A TrivelinNatália R AmorimVera L CapelozziMarcelo M MoralesBianca GutfilenSergio A L de SouzaDaniel J WeissBruno L DiazPatricia Rieken Macêdo RoccoPublished in: Stem cell research & therapy (2019)
Compared to nonpreconditioned cells, EPA-preconditioned AD-MSCs yielded further reductions in the lung and distal organ injury, resulting in greater improvement in sepsis severity score and higher survival rate in CLP-induced experimental sepsis. This may be a promising therapeutic approach to improve outcome in septic patients.
Keyphrases
- acute kidney injury
- septic shock
- adipose tissue
- intensive care unit
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- minimally invasive
- mesenchymal stem cells
- peritoneal dialysis
- insulin resistance
- bone marrow
- prognostic factors
- high glucose
- cell cycle arrest
- diabetic rats
- metabolic syndrome
- oxidative stress
- endothelial cells
- patient reported outcomes
- skeletal muscle