Synthesis and biological evaluation of the ascidian blood-pigment halocyamine A.
Hugo K H FongJean Michel BrunelArlette LongeonMarie-Lise Bourguet-KondrackiDavid BarkerBrent R CoppPublished in: Organic & biomolecular chemistry (2018)
Synthesis of the antimicrobial marine natural product halocyamine A has been achieved utilizing a combination of Sonogashira coupling, ruthenium complex/ytterbium triflate catalyzed hydroamidation and solid-phase peptide synthesis (SPPS) chemistry. The synthetic natural product exhibited only modest levels of antibacterial activities but significant antioxidant activity.