No Correlation between Anti-drug Antibodies and Therapeutic Response in Tunisian Patients with Chronic Inflammatory Diseases Treated by TNF Blockers.

Selma BoudenLilia LaadharJihene SouaMeriam Ben MessaoudLeila RouachedImene AyadiOlfa SaidaneAicha Ben TekayaInes MahmoudSonia RekikHéla Sahli SrairiRawdha TekayaSyrine BellakhalMonia FekihLeila AbdelmoulaMaryem Kallel

Published in: Current rheumatology reviews (2024)

In our study, the presence of ADAb and low trough levels seem to not affect the therapeutic response in patients on TNF alpha antagonists. Other tracks more than immunogenicity should be investigated to explain the loss of response to these biotherapies.

Keyphrases

end stage renal disease
rheumatoid arthritis
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
oxidative stress
emergency department
patient reported outcomes
mass spectrometry
electronic health record
single molecule