Studies in Zebra Fish and Rat Models Support Dual Blockade of EP2 and EP4 (Prostaglandin E 2 Receptors Type 2 and 4) for Renoprotection in Glomerular Hyperfiltration and Albuminuria.
Aikaterini KourpaAngela SchulzEva MangelsenDebora Kaiser-GrafNils KoppersMonika StollMichael RotheMichael BaderBettina PurfürstSéverine KunzThomas GladytzThoralf NiendorfSebastian BachmannKerim MutigJuliane BolbrinkerDaniela PanakovaReinhold KreutzPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
in the development of albuminuria in GH and support the renoprotective potential of combined pharmacological blockade of EP2 and EP4 receptors. These data support further translational research to explore this therapeutic option and a possible role of circadian clock genes.