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Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DSS-induced colitis.
Jun-Hua Li
Yu Chen
Zheng-Hao Ye
Li-Ping Chen
Jia-Xin Xu
Jian Han
Lin Xie
Shuai Xing
De-An Tian
Ursula Seidler
Jia-Zhi Liao
Fang Xiao
Published in:
Precision clinical medicine (2024)
Our study suggests that the suppression of MyD88 might be associated with unfavorable changes in the composition of gut microbiota, leading to NLR-mediated immune activation and intestinal inflammation.
Keyphrases
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toll like receptor
oxidative stress
inflammatory response