Balancing the Virulence and Antimicrobial Resistance in VISA DAP-R CA-MRSA Superbug.
Rossella SalemiAlessandra ZegaElvira AgugliaFlavia Lo VerdeGiuseppe PigolaStefania StefaniViviana CafisoPublished in: Antibiotics (Basel, Switzerland) (2022)
Our data show that VISA DAP-R CA-MRSA shifts the potential hypervirulent behavior of CA-MRSA towards the acquisition and maintenance of extensive AMR, by a decrease in virulence and biological costs mediated by a "compensatory modulatory mutation" silencing the Agr quorum-sensing cascade.