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Dysfunctional mitochondria elicit bioenergetic decline in the aged heart.

Pasquale MoneEsther Densu AgyapongGiampaolo MorcianoStanislovas S JankauskasAntonio De LucaFahimeh VarzidehPaolo PintonJoseph H Taube
Published in: The journal of cardiovascular aging (2024)
Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.
Keyphrases
  • cell death
  • heart failure
  • endothelial cells
  • reactive oxygen species
  • atrial fibrillation
  • left ventricular
  • risk assessment
  • stress induced
  • single molecule