Cell polarity (the 'four lines') distinguishes gastric dysplasia from epithelial changes in reactive gastropathy.
Kevin M WatersKevan J SalimianNaziheh AssarzadeganDanielle HutchingsElias P MakhoulAnnika L WindonMary T WongLysandra VoltaggioElizabeth A MontgomeryPublished in: Histopathology (2020)
Surface cell polarity (the four lines) was lost in all gastric dysplasia biopsies with evaluable surface epithelium and maintained in all biopsies of reactive gastropathy. Caution should be taken in using this feature adjacent to erosions in reactive gastropathy.