Biomechanical Regulation of Hematopoietic Stem Cells in the Developing Embryo.

Paulina D HortonSandeep P DumbaliKrithikaa Rajkumar BhanuMiguel F DiazPamela L Wenzel

Published in: Current tissue microenvironment reports (2021)

Despite challenges of measuring and modeling biophysical cues in the embryonic HSC niche, the past decade has revealed critical roles for mechanotransduction in governing HSC fate decisions. Lessons learned from the study of the embryonic hematopoietic niche promise to provide critical insights that could be leveraged for improvement in HSC generation and expansion ex vivo.

Keyphrases

induced apoptosis
cell cycle arrest
bone marrow
single cell
oxidative stress
endoplasmic reticulum stress
pregnant women
cell death
machine learning
artificial intelligence
deep learning