Hydroxyurea reduces infections in children with sickle cell anemia in Uganda.

Ruth NamazziCaitlin BondAndrea L ConroyDibyadyuti DattaAbner TagoolaMichael J GoingsJeong Hoon Jang Russell E WareRobert OpokaChandy C John

Published in: Blood (2024)

After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001).

Keyphrases

respiratory tract
young adults
chronic kidney disease
sickle cell disease
risk factors
early onset
combination therapy
replacement therapy