Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors.
Keith T SchmidtAlwin D R HuitemaThomas P C DorloCody J PeerLisa M CordesLinda SciutoSusan WroblewskiYves PommierRavi A MadanAnish ThomasWilliam Douglas FiggPublished in: Cancer chemotherapy and pharmacology (2020)
The popPK model confirmed nanoparticle behavior of conjugated CPT and mechanistically characterized CPT release from NLG207. The current analysis provides a strong foundation for future study as a potential predictive tool in ongoing NLG207 clinical trials.