Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure.

Tao LinShanshan WangStefan MunkerKyounghwa JungRicardo U Macías-RodríguezAstrid Ruiz-MargáinRobert SchierwagenHui LiuChen ShaoChunlei FanRilu FengXiaodong YuanSai WangFranziska WandrerChristoph MeyerRalf WimmerRoman LiebeJens KrollLong ZhangTobias SchiergensPeter Ten DijkeAndreas TeufelAlexander MarxPeter R MertensHua WangMatthias Pa EbertHeike BantelEnrico De ToniJonel TrebickaSteven DooleyDonghun ShinHuiguo DingHong-Lei Weng

Published in: Hepatology (Baltimore, Md.) (2021)

These results highlight a crucial role of the follistatin-controlled activin-HNF4α-coagulation axis in determining the clinical outcome of massive hepatocyte loss-induced ALF. The effects of insulin and glucagon on follistatin suggests a key role of the systemic metabolic state in ALF.

Keyphrases

liver failure
hepatitis b virus
drug induced
type diabetes
liver injury
nuclear factor
high glucose
diabetic rats
oxidative stress
glycemic control
intensive care unit
immune response
endothelial cells
skeletal muscle
respiratory failure