CSN6 Mediates Nucleotide Metabolism to Promote Tumor Development and Chemoresistance in Colorectal Cancer.

Shaomin Zou Baifu Qin Ziqing Yang Wencong Wang Jieping Zhang Yijing Zhang Manqi Meng Junyan Feng Yunling Xie Ling Fang Lishi Xiao Peng Zhang Xiangqi Meng Hyun Ho Choi Weijie Wen Qihao Pan Bart Ghesquiere Ping Lan Mong-Hong Lee Lekun Fang

Published in: Cancer research (2023)

CSN6 deficiency inhibits colorectal cancer development and chemoresistance by downregulating PHGDH to block nucleotide biosynthesis, providing potential therapeutic targets to improve colorectal cancer treatment.

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