Palladium-Catalyzed β -C(sp 3 )-H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands.

2-Pyridone ligand-facilitated palladium-catalyzed direct C-H bond functionalization via the transient directing group strategy has become an attractive topic. Here, we report a Pd-catalyzed direct β -C(sp 3 )-H arylation reaction of tertiary aliphatic aldehydes by using an α -amino acid as a transient directing group in combination with a 2-pyridone ligand.