Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus.
Saifur RahmanDivya SagarRichard N HannaYaima L LightfootPragnesh MistryCarolyne K SmithZerai MannaSarfaraz HasniRichard M SiegelMiguel A SanjuanRoland KolbeckMariana J KaplanKerry A CaseyPublished in: Annals of the rheumatic diseases (2019)
Based on our results, SLE LDG display an activated phenotype, exert proinflammatory effects on T cells and do not exhibit MDSC function. These results support the concept that LDG represent a distinct proinflammatory subset in SLE with pathogenic potential, at least in part, through their ability to activate type 1 helper responses.