Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis.

Ingo Winschel Anne Willing Jan Broder Engler Mark Walkenhorst Nina Kursawe Lars Binkle Marcel Seungsu Woo Lena Kristina Pfeffer Jana K Sonner Uwe Borgmeyer Sven Hendrik Hagen Benjamin Grünhagel Janna M Claussen Marcus Altfeld Nicolaus Kröger

Published in: Biology of sex differences (2024)

Our results demonstrate that CD99 is sex-specifically regulated in healthy individuals and MS patients and that it is involved in T cell costimulation in humans but not in mice. CD99 could potentially contribute to MS incidence and susceptibility in a sex-specific manner.

Keyphrases

multiple sclerosis
mass spectrometry
end stage renal disease
ejection fraction
ms ms
nk cells
prognostic factors
type diabetes
transcription factor
white matter
metabolic syndrome
skeletal muscle