Bis(bicyclo[1.1.1]pentyl)chlorophosphine as a Precursor for the Preparation of Bis(bicyclo[1.1.1]pentyl)phosphines.

Dialkylchlorophosphines are among the most versatile building blocks for tertiary phosphine ligands, but their synthesis relies on the nucleophilic substitution of PCl 3 , leaving substituents that require P-H precursors largely inaccessible. The primary phosphine reagent iPr 2 NPH 2 ·BH 3 can serve as a doubly protected PH 2 Cl proxy, enabling the synthesis of bis(bicyclo[1.1.1]pentyl)chlorophosphine (Bcp 2 PCl) for the first time. Bcp 2 PCl serves as a general reagent for the preparation of a family of bis(bicyclo[1.1.1]pentyl) alkyl- and arylphosphines, including new members of privileged phosphine ligand scaffolds.