Synthesis on NIR-II multifunctional imaging and photothermal therapy of a novel water-soluble molecule.

The synthesis of water-soluble symmetric molecules with D-A-D structure was reported. The compound was connected by π bridge with 2-bromofluorene external PEG2000 as the shielding unit and donor component, and pyrrolopyrrole (DPP) as the acceptor unit. The donor-acceptor-donor (D-A-D) double donor fluorescent molecule P2-DPP was obtained by coupling reaction. The absorption peak and emission peak of the fluorescent molecule P2-DPP are 600 nm and 1020 nm, respectively. It has potential excellent imaging characteristics. It does not need to use nanoparticles formed by the DSPE-MPEG amphiphilic block to form micelles. The quantum yield reaches 0.6% and the penetration depth can reach 10 mm. The chemical is capable of achieving liver and renal metabolism. It has a good application prospect in the photothermal therapy of mouse tumors and realizes the integration of biological diagnosis and treatment. This article is protected by copyright. All rights reserved.