NUAK1 coordinates growth factor-dependent activation of mTORC2 and Akt signaling.
Mario PalmaElizabeth RiffoAlejandro FariasViviana Coliboro-DannichLuis Espinoza-FrancineEmilia EscalonaRoberto AmigoJosé L GutiérrezRoxana PincheiraAriel F CastroPublished in: Cell & bioscience (2023)
Our results showed that NUAK1 kinase controls mTOR subcellular localization and induces Akt phosphorylation, demonstrating that NUAK1 regulates the growth factor-dependent activation of Akt signaling. Therefore, targeting NUAK1, or co-targeting it with Akt or mTOR inhibitors, may be effective in cancers with hyperactivated Akt signaling.