Relationships between plasma biomarkers, tau PET, FDG PET, and volumetric MRI in mild to moderate Alzheimer's disease patients.

Dawn C MatthewsJefferson W KinneyAaron RitterRandolph D AndrewsErin N Toledano StromAna S LukicLauren N KoenigCarolyn RevtaHoward M FillitKate ZhongBabak TousiJames B LeverenzHoward H FeldmanJeffrey Cummings

Published in: Alzheimer's & dementia (New York, N. Y.) (2024)

Plasma pTau-181 and GFAP correlated with regional and global tau PET in mild to moderate AD.NfL correlated with FDG PET and cognitive endpoints but not plasma pTau-181 or tau PET.Volume and FDG PET showed strong relationships to tau PET, one another, and cognitive status.Temporal volumes most strongly predicted decline in both MMSE and ADAS-cog.Volume and plasma biomarkers can enrich for elevated tau PET with age a significant covariate.

Keyphrases

pet ct
positron emission tomography
pet imaging
computed tomography
cerebrospinal fluid
end stage renal disease
chronic kidney disease
contrast enhanced
cognitive decline
patient reported outcomes